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Cleveland's NDI Medical continues to grow rapidly in neuro-stim field

When Geoff Thorpe founded NDI Medical in 2002 with his neurostimulation device for bladder control, he saw a market with a lot of potential. The company sold its MEDSTIM device to Medtronic in 2008, kept the NDI name and branched into developing and commercializing new neurostimulation device companies.
The move has proved successful. NDI has launched two companies and has grown to 32 employees, 21 of whom work in NDI’s Cleveland headquarters. The company also has offices in North Carolina and Minnesota. Most recently, NDI Medical named Marilyn Eisele as president of the company. She has been with NDI about a year, previously serving as vice president of finance and CFO.
“What attracted me to the company was the innovation coming out of the collective enterprise,” Eisele says. “We took a step back after we sold the company in 2008 and decided to reinvent and continue the business as a development company where we develop new therapies.”
Since selling the company and regrouping as a developer of new technologies, NDI Medical has raised $17 million in private equity and another $9 million in grants and loans. In 2010, the company launched Checkpoint Surgical, which makes a device that allows surgeons to locate nerves and muscles before making an incision, and SPR Therapeutics, which develops nerve stimulation devices for pain management. Sales have doubled each year since Checkpoint was launched.
“In some ways we are a development company, and in some ways we’re an incubator company,” says Eisele. “We’re able to develop medical devices so each portfolio company doesn’t need its own team of engineers. It’s a very cost-effective way to use research.”
NDI Medical is in the process of launching a third company in the next few months.

Source: Marilyn Eisele
Writer: Karin Connelly

'Big Idea Challenge' in Cincy offers rewards for innovative solutions

Part crowd-sourcing, part-buzz-generating and all focused on civic progress and innovation, the Greater Cincinnati's Foundation's freshly launched "The Big Idea Challenge" guarantees funding for big ideas with community support and the potential for high impact.

Envisioned as a way to engage the broader community in problem-solving and program development, the Challenge offers a public platform for anyone with an idea that could make the city a more vibrant and healthy place. Online submissions answering the question, "What's your Big Idea for a more prosperous Greater Cincinnati?" will be accepted from June 3 through July 29. In August, the field will be narrowed to 21 finalists; in September, public voting will determine the winners in each of seven categories.

"This is a groundbreaking way for one of the largest funders in our region to connect with the entire community," says Elizabeth Edwards, CEO of Metro Innovation and founder of Cincinnati Innovates. Her web platform, CrowdSpark, will host the Challenge. She's also part of the Big Idea Brain Trust, local thought-leaders who helped shape and refine the project with Greater Cincinnati Foundation leaders.

GCF is looking for ideas that will impact Cincinnati in one or more of seven categories:
• Strong Communities
• Cultural Vibrancy
• Job Creation
• Environmental Stewardship
• Educational Success
• Health & Wellness
• Economic Opportunity

The application process is streamlined — applicants, aged 18 and up, need only submit their contact information, a title, a 140-character description (great for Twitter) and a 2,000-character detailed description. Applicants whose ideas are chosen as winners will receive cash prizes; then, GCF will award $5,000 grants to area non-profits with the capacity to implement the winning "Big Ideas." One overall "Big Idea" will add a $50,000 grant to a complementary non-profit's coffers to "kickstart" the implementation of the idea.

By Elissa Yancey
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AAF Cincinnati and dunnhumby partner to start Cincinnati Digital Dialogue

American Advertising Federation Cincinnati is partnering with dunnhumbyUSA to set the stage for the city's first consumer-focused digital marketing conference.

D2, or Cincinnati Digital Dialogue, will be held Sept. 11 and 12 at the Horseshoe Casino downtown. The conference will focus on putting consumers at the center of digital marketing and business planning.

"If the customer is not at the center of your marketing, then what is?" says dunnhumbyUSA Executive Vice President of Communications and Media Matt Nitzberg. "I think people can get caught up in technology and technique because of the interesting things that can be done. But the techniques that will work are the ones that will connect with customers."

Digital marketing through websites, social media and video is more accessible and available than ever. And businesses large and small are using digital media to promote their brands with varying levels of success. The conference will help businesses and agencies focus those efforts to their particular customers.

"This is for professionals who want to put the consumer at the center of their digital marketing strategy," Nitzberg says. "It's for everyone, from the big retailer to the small ad agency."

The conference is a good fit for the Queen City, which has the highest per-capita concentration of branding professionals in the world. It's home to P&G, to the largest consumer goods manufacturer; Kroger, the country's largest supermarket retailer; and Macy's, the country's largest department store chain.

Organizers will spend the summer ironing out conference details, including speakers, session topics and registration information. To stay updated on the latest news, or for more information on speaker and sponsor packages, go to www.d2cincinnati.com or follow D2 Cincinnati on Twitter @d2Cincinnati #d2Cincy.

By Feoshia H. Davis
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Bad Girl Ventures congratulates Cleveland finalists in spring biz plan competition

Earlier this  month in Cleveland, Bad Girl Ventures celebrated nine finalists in its business plan competition during its spring 2013 graduation ceremony at The Galleries at CSU, announcing the winner of its $25,000 BGV loan and other awards.

Jewels Johnson, owner of the Sugar Plum Cake Company, earned the $25,000 loan for her custom cake bakery. She plans to use the loan to open and expand her new physical store and offices, as well as develop her Devour! Gourmet Baking Mixes line.
“We were very impressed with her approach and creativity,” says Reka Barabas, director of BGV Cleveland. “Jewels was super-energetic during the entire course. She went the extra mile and followed up.”
The nine women-owned businesses spent nine weeks in BGV’s business course, hashing out their business plans and tweaking their businesses. The class culminated with the participants giving a 60-second pitch to a selection committee.
In addition to the grand prize, Su Nimon of Journey Art Gallery and Kelli Handley of The Agrarian Collective each received $5,000 loans from a private giving circle. It was also announced that Jillian Davis of Toast Wine Bar, a BGV Fall 2012 finalist, received a loan from BGV partner the Economic Community Development Institute (ECDI).
“All of the finalists are impressive because of their huge passion in what they do,” says Barabas. BGV will continue to work with its partners in the upcoming weeks to help the other finalists secure business loans.
BGV will be accepting applications for its fall business class from June 1 through Sept. 1.

Source: Reka Barabas
Writer: Karin Connelly

Five Cincinnati Uptown organizations receive awards for community commitment

Earlier this month, members of Cincinnati's Uptown community gathered for the Uptown Business Celebration, presented by Uptown Consortium and Uptown Rentals/North American Properties. Five Uptown organizations walked away with awards for business excellence and commitment to the community.
In order to be eligible for an award, businesses demonstrated strong commitment to the Uptown community, success in meeting the organization’s mission and sustainable businesses practices. They also encouraged others to follow their lead. Awards were given in five categories: Small Nonprofit of the Year (25 of fewer employees), Large Nonprofit of the Year (more than 25 employees), Community Champion, Small Business of the Year (50 or fewer employees) and Large Business of the Year (50 or more employees).
The Small Nonprofit award went to the Clifton Heights Community Urban Redevelopment Corporation and Large Nonprofit to Cincinnati Children’s Medical Center. Avondale resident and avid volunteer Patricia Milton won the Community Champion award; the Small Business award went to UC's DuBois Bookstore; and the Large Business award to Uptown Rental Properties.
Keynote speaker Benjamin Carson, Sr., M.D., who overcame poverty and a difficult childhood, is currently a full professor of neurosurgery, oncology, plastic surgery and pediatrics at Johns Hopkins School of Medicine. He has directed the pediatric neurosurgery program at Johns Hopkins Children’s Center for more than 25 years. Carson's many awards include 60 honorary doctorate degrees and the Presidential Medal of Freedom, which is the highest civilian honor.
Carson encouraged those at the awards ceremony to “elevate themselves” to make things better. He also shared his philosophy of success, which is “THINK BIG—talent, honesty, insight, nice, knowledge, book, in-depth learning and God.”
Uptown neighborhoods are Avondale, Clifton, Corryville, Clifton Heights, Fairview, University Heights and Mt. Auburn.
By Caitlin Koenig
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Dublin-based IC3D printers launches crowd funding campaign to manufacture raw material locally

Dublin-based IC3D Printers has launched a crowd funding campaign through Indiegogo to manufacture 3D printing material locally in Ohio.
The campaign is set to run for 30 days with a goal of raising $20,000 to compliment existing capital. Michael Cao, Owner and Founder of IC3D, says he was persuaded by a friend to use crowd funding to avoid getting banks and interest rates involved. Funds will go toward equipment, leasing factory space, buying materials in bulk, and hiring an operator.
Cao’s goal is to address today’s costly supply chain model of manufacturing 3D printing components. Currently, outside manufacturers supply the plastic filament needed for Cao's 3D printers. Even worse, that filament is designed for use in the plastic welding industry. This sometimes results in an inferior product that may be contaminated.
“The problem is [the plastic welding industry] has very different requirements,” explains Cao, noting that 3D printing is still a young industry. “It has lower quality of requirements, such as cleanliness” and filament diameter. Cao's solution is to manufacture his own 3D printing material in Ohio exclusively for the 3D printing market, allowing him to take some links out of the current supply chain model.

Cao came up with the idea after working as a designer and builder of desktop 3D printers. Customers began asking Cao for filament printing material. At first, he gave it away for free. As this became costly, he began purchasing in bulk, but noticed some quality issues. “It was a frustrating experience,” says Cao, recalling customer complaints. He decided to take his experience in plastics and as an automotive engineer to produce the necessary material himself. Ohio and IC3D’s customers all stand to benefit.
“By obtaining the raw materials and packing the materials ourselves, we’re cutting out those layers from the current supply chain,” explains Cao. “That cost savings will be passed down to the customers.”
Source: Michael Cao
Writer: Joe Baur

Brain surgeons get a practice run with simulator from Elyria-based Surgery Theater

For a number of years, pilots have used virtual reality simulators to practice critical missions before taking to the skies. Thanks to a revolutionary new virtual reality training tool developed by Elyria’s Surgical Theater, LLC, surgeons now have a way to practice brain surgery before setting foot in the operating room.
The Surgery Rehearsal Platform (SRP) simulator consists of a desk top computer, a portable laptop system, software, controllers and 3D glasses.
“Using standard CT and MRI images from any patient, the SRP generates accurate models in 3D that show the interaction between life-like tissue and surgical instruments,” explains Moty Avisar, Surgical Theater president and CEO. “The tissue responds realistically to actions taken by the surgeon, enabling pre-surgery planning and rehearsal with complete accuracy.”

Beyond practicing on standard CT and MRI images, surgeons can also use unique images taken of the patient who will be undergoing surgery.
“Using the SRP prior to a procedure enables a surgeon to evaluate, experiment and do a ‘dry run’ on his or her approach beforehand, resulting in a better-prepared surgeon,” Avisar states. “Studies will be done to confirm this, but our belief is that SRP training will lead to improved patient outcomes and reduced risk.”
The Surgery Rehearsal Platform received full FDA approval in February. The SRP’s unique patient-specific capability is one of the key innovations that led to FDA approval, he notes. According to Avisar, it’s the only patented and FDA-cleared training platform for cerebral and spine pre-surgery rehearsal in the marketplace.
The SRP, which took approximately three years to develop, supports several cerebral procedures, including aneurysm repair and tumor resection. The team is working to add capabilities to support other brain-related procedures and spine surgeries.
According to Avisar, the first SRP was recently sold to University Hospital Case Medical Center, where it is being used on a regular basis.

The company, which started with one person in 2010, received funding from the Ohio Third Frontier, private investors and angel groups. It plans to expand to 15 employees by the end of the year.
Source:  Moty Avisar, Surgical Theater, LLC
Writer:  Lynne Meyer

Blackstone Launchpad opens fourth location on Case Western campus

The fourth Blackstone LaunchPad opened on the CWRU campus on April 23, providing a place for aspiring entrepreneurs to gather, learn and get advice.

“LaunchPad is aimed at students seeing it and saying, ‘I have an idea,’” says Deborah D. Hoover, president and CEO of the Burton D. Morgan Foundation. “It’s aimed at students walking in and talking to people and an idea takes off.”
The Burton D. Morgan Foundation in Hudson and the Blackstone Charitable Foundation announced in November 2011 that they had committed $3.2 million over three years to open LaunchPad locations in Northeast Ohio to train area student entrepreneurs.
The LaunchPad is a venture coach program developed at the University of Miami, Florida in 2008. The program provides participants with advice and mentorship to take business ideas to fruition. Students are matched up with venture coaches to guide them through the development process.
The other Northeast Ohio LaunchPads are on the campuses of Baldwin Wallace University, Lorain County Community College and Kent State University. The goal is to create 150 new sustainable companies in the next five years, which could generate as many as 3,000 jobs. Hoover says they expect to exceed that goal.
More than 40 students already are registered with the CWRU LaunchPad and 16 are exploring their business ideas. “More than 400 student ventures are underway among the four campuses,” says Hoover. “We think that’s pretty great.” Registration is ongoing.
Nearly 200 people turned out for the opening in CWRU’s Thwing Center. “It was great, we were really pleased with the way it went,” Hoover says of the opening. Attendees included Case president Barbara Snyder and Bob Sopko, director of the CWRU LaunchPad, as well as Joan Solotar, chair of the Blackstone Charitable Foundation and Vinny Gupta, chair of the Ohio Board of Regents.

Source: Deborah D. Hoover
Writer: Karin Connelly

UC researchers develop smarter, solar-powered water filter

Researchers at the University of Cincinnati have developed tiny, solar-powered water filters that target and remove carcinogens and antibiotics from lakes and streams.

These protein-based filters are smaller in diameter than a human hair, and work differently than current surface water filters that are made of activated carbon. Those carbon filters work much like the ones in home water filtration systems.

"In Cincinnati, we have one of the largest activated carbon treatment facilities in the United States," says David Wendall, a faculty researcher and environmental engineering professor at UC. "But what the current filters do is bind a lot of different [non-dangerous] compounds; it will will coat the filter very quickly."

UC's research was published in the "Nano Letters" journal. It showed the new filters absorbed 64 percent surface water antibiotics, compared to 40 percent absorbed by current filtering technology.

The research is important because there is growing scientific evidence of harmful effects of the hormones and antibiotics that work their way into our lakes and streams.

"We're starting to understand that birth control is feminizing fish, and antibiotics promote resistance in certain organisms," says Wendall. "It's what is contributing to superbugs that resist to antibiotic treatment. We're learning more about what happens when we dump antibiotics into the environment."

Generally, the contaminates arrive in waterways from runoff through farms or when we flush or trash our medicines.

"The main sources are from farms," Wendall says. "They put antibiotics in animal feed so they will grow fast and stay healthy. But some of their waste ends up in the rivers as runoff, where [the antibiotics] don't break down, and it ends up contaminating our water."

The filter at UC was developed in 2010. Testing has proven successful in specifically targeting antibiotics and other harmful materials.

Wendall describes the filters as "selective garbage disposals." Filtering ability is fueled by sunlight, and the filters actually preserve antibiotics in a way that famers can reuse if filters are recovered.

The university's research is continuing to be tested and refined, Wendall says. But current work could be used practically in three to five years.

By Feoshia H. Davis
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Arcade Legacy in Cincinnati is a destination for gamers

Arcade Legacy is a mecca for gamers, with more than 68 arcade machines ready to be played and no quarters needed. Gamers can pay at hourly or monthly rates. Arcade Legacy also buys, sells and trades pretty much anything that has to do with gaming and movies.   

Old-school and high-tech at the same time, Arcade Legacy is a veritable museum of video game history. Classics like the Missile Command arcade cabinet and the Jurassic Park pinball table sit in the same room as Guitar Hero. There’s also the Teenage Mutant Ninja Turtles side-scrolling brawler game, which could be found in nearly every respectable pizza place 25 years ago.

There are also more than 1,000 console games that guests can play on TVs or on a giant wall. Visitors can essentially visit  the coolest nerd on the block—in this instance, Jesse Baker. Baker, the store’s founder, grants them unlimited access to his massive gaming treasure room for a nominal fee.

Located in the sparsely populated Cincinnati Mall, Arcade Legacy is a beacon for dedicated gamers and shoppers. High demand for birthday parties and social events has led Baker to consider expanding his business to a larger location in the mall, which is undergong a major overhaul.

In celebration of its first anniversary, Arcade Legacy launched a mission to offer every single Nintendo Entertainment System game that’s been made—something like 760 titles—in alphabetical order. Baker has just hit the letter “B.” Since January, gamers have met at Arcade Legacy on Wednesdays for “Beat it or Die Trying.” Anyone can sign up to play their favorite games in the NES’ massive library and show off in front of a crowd.

By Sean Peters

TOA Technologies expands global presence with largest customer to date

TOA Technologies announced that Madrid, Spain-based Telefonica has chosen TOA's mobile workforce management software to manage its worldwide field technicians. Telefonica, which is one of the largest telecom companies in the world, chose TOA for its cloud-based ETADirect technology and its ability to ramp up operations quickly in multiple locations.
“It was a fairly long selection process,” says TOA vice president of worldwide marketing John Opdycke. “Telefonica originally thought it would be an on-premise solution, but then they realized the cloud-based solution would allow them to go one country at a time.”
TOA will implement its products first in Brazil, followed by Spain, Argentina, Chile, Columbia and Peru. Eventually, TOA will be in 24 countries with Telefonica. “There’s nothing anyone needs except access to a browser,” explains Opdycke of why TOA was attractive to Telefonica. “They can be non-standard, browser agnostic and platform agnostic. Telefonica needed that flexibility.”
Telefonica is TOA’s largest customer to date in terms of size. More important, Opdycke says, is Cleveland’s increasingly strong presence in the global technology marketplace. “We’re proud to represent the Cleveland technology market and the international market,” he says. “TOA is one of the leading companies in the Cleveland market that is really doing international business.”
TOA employs 56 people in its Cleveland headquarters, and another 454 worldwide. The Telefonica deal will add employees to TOA in Spain and Brazil, and perhaps Cleveland. Telefonica’s CTO and other team members are planning a visit to Cleveland.
In the meantime, TOA is in the midst of expanding its headquarters from 8,200 square feet to 17,000 square feet. The company was also recently named as a finalist as Tech Company of the Year in the 2013 NEOSA Tech Week Best of Tech Awards.

Source: John Opdycke
Writer: Karin Connelly

3DLT launches online 3D printing template market, gains national attention

3D printing is fast becoming an accessible, affordable way to create products, pieces and prototypes. Machine parts, toys and even jewelry can be printed quickly and with precision using 3D printing.

A new Cincinnati company is leading in the industry—3DLT—an online marketplace where users can purchase and download 3D printer templates. Using home printers or 3DLT's printer network, users can print pre-designed products in a variety of materials—from plastic to metal and even leather.

"We work with industrial designers across the world," says 3DLT's founder, Pablo Arellano, Jr. "They love to design, and we have them build these templates."

Arellano launched 3DLT at TechCrunch Disrupt NY in early May. The Cincinnati native is working with a team of co-founders to get the company off the ground. Arellano has founded several other startups, and is a former Procter & Gamble brand manager.

Arellano described the company as the iStockphoto of 3D printing.

"I'm a big fan of iStockphoto," he says. "I thought the next thing you can potentially download is 3D templates, and I wanted to be in that space. I've been working on this full-time for the past four months."

3DLT templates include bracelets, rings, mesh lampshades, eyeglass frames, shoes and iPhone 4S protectors.

The self-funded company is beginning to seek investors. 3DLT already has gotten national attention, and has been featured in TechCrunch, Wired, The Verge, Fast Company, Venture Beat and Popular Science. It's also a winner of the 2012 X-LAB competition, and has moved into the new Cintrifuse incubator.

Arellano believes most of the companies initial users will be commercial, but as 3D printer prices drop, more consumers will begin to print their own products.

"The prices are dropping very quickly," he says. "It's already happening."

By Feoshia H. Davis
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Student-owned distributor business wins prize at Cleveland's Entrovation

Danny Sheridan comes from a family of entrepreneurs -- his father invests in small tech businesses and deals in commercial real estate for medical officers, and his mother is a marketing consultant. So it was only natural that the junior at Beachwood High School would start his own business. After finding he had a knack for selling things on eBay, Sheridan started Woodside Distributors, distributing energy efficient LED lights for Solon-based Mr. Beams.
“Mr. Beams didn’t have a lot of eBay, but I was really good at eBay,” says Sheridan. “When I ran into them I immediately was able to distribute their products online. I was able to add my area of expertise, and now we’re on Amazon and other places.”
Sheridan’s business has quadrupled in the past few months and he expects to reach $100,000 in sales by the end of the year.
Sheridan, who is president of the Beachwood High School Business Club, set up a booth at Entrovation on April 19 to showcase his company and the products he distributes. “There were a ton of people -- 1,000 or so -- who just came by to say hi,” he recalls. “The biggest reaction was, ‘Hey, you’re just a kid.’ Then it was, ‘Wow, he’s actually selling.’ I was fortunate; I made a few hundred bucks that day.”
In fact, Sheridan won the Innovative Entrepreneur of the Year award, sponsored by the Burton D. Morgan Foundation. He received the top prize of $3,000. “I’m excited to buy more inventory and expand even faster,” he says.
Sheridan’s business is growing so fast, he’s looking for new fulfillment options. “I’ve been using Amazon to do more fulfillment,” he explains. “But it’s getting to the point I can’t ship from my house any more. The mailman can’t keep up.”

Source: Danny Sheridan
Writer: Karin Connelly

Wright State University breaks ground on $37 million research facility

Wright State University (WSU) has broken ground on a $37 million research facility, priming the region to take a leading role in the neuroscience field.
Dr. Robert Fyffe, Vice President for Research at WSU, says the idea of the new facility is to bring people together from different fields. “This facility will bring create synergies between people and lead to innovation,” he says. “If you can get people working together side-by-side with the recourse you need for truly collaborative, disciplinary work, you can actually achieve much more than if people are working in isolation.”
The new facility, scheduled for completion in February of 2015 and occupancy by spring of 2015, will house a diverse array of equipment necessary for the variety of fields of research that will be taking place. “There will be the ability to do everything from cellular molecular imaging to looking at MRI scans,” details Fyffe. “There will also be a good deal of specialized equipment in terms of advanced manufacturing and related areas.”
Similar to the vision of the facility itself, funding was made possible by what Dr. Fyffe describes as “a number of mechanisms,” including the state of Ohio’s budget for higher education and bonds issued by the university to assist with construction. This, combined with President Obama’s recently launched Brain Initiative, shows “neuroscience is an area that is moving again to the forefront of research,” Fyffe believes. Best of all, it allows Dayton and the state of Ohio to lead the way in research and innovation.
“I think it will be a strong beacon to continue to attract neuroscience research,” says Fyffe of the new research center, noting the alignment of interests between WSU and nearby Wright-Patterson Air Force Base. “The state is beginning to prime itself to step forward in the neuroscience field.”
Source: Dr. Robert Fyffe
Writer: Joe Baur

Dayton's NovoSource promises to decrease cost of knee replacement device

According to research released in the Journal of the American Medical Association last year, hospitals in 2010 performed 243,802 knee replacement surgeries, up from 93,230 in 1991. According to the study, annual demand for knee replacement surgeries could reach 3.5 million by 2030. The researchers attribute the potential increase to various factors, including aging baby boomers.

The popularity of the procedure and the price of knee replacement devices are contributing to rising health care costs, says Harold Linville, co-founder and chairman of Dayton’s NovoSource.
“The market for knee replacement devices is dominated by three or four companies,” he explains. “They provide great products that produce excellent results, but their overhead is huge, with large facilities, big staffs, expensive advertising and a costly distribution system.”
NovoSource is introducing its own knee replacement device. “It’s being manufactured by one of the companies the big players use to make their products,” he says. “Our device is made of the exact same materials and has the exact same functionality. The quality is the same. The difference is that ours will be much less expensive.”
The reason, according to Linville, is NovoSource’s streamlined business model. 

“We have a significantly lower overhead, with fewer employees and one sales person,” he says. “We also have better supply chain management because we’re working with our suppliers to establish long-term manufacturing agreements. Our approach also means we can maintain a lower inventory without tying up money.”
The company won’t be doing any advertising and will sell directly to hospitals and surgeons. “In terms of overcoming skepticism about considering our device, we’re able to provide data to prove that the quality of our product is just as good as anything else available on the market,” he states.
NovoSource’s knee replacement device is under final review by the FDA, and results are expected soon. The company plans to start distribution in Florida with the surgeons it worked with to develop the product.

NovoSource received $1.2 million in funding from the Dayton Development Coalition, with the rest coming from angel investors.

Source:  Harold Linville, NovoSource
Writer:  Lynne Meyer
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