Cleveland : Innovation + Job News

Great Lakes NeuroTechnologies (GLNT), which creates biomedical technologies for the treatment of movement disorders, announced last week that they will be leading a study to improve algorithms for deep brain stimulation in treating Parkinson’s disease.

The study will use GLNT’s Kinesia technology and is funded by a $283,828 phase I Small Business Innovative Research grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke. It will take place at the University of Alabama at Birmingham this spring.
 
Deep brain stimulation involves implanting an electrode in a certain area of the brain to treat the side effects of Parkinson’s disease and other movement disorders. But the technology has varied results. GLNT hopes to improve the outcomes.
 
“Implanting the electrode is more art than science right now,” says Dustin Heldman, biomedical researcher and principal investigator for GLNT, explaining that outcomes depend on amplitude and frequency -- leaving a lot of variables on the individual programmer.
 
“With the existing Kinesia system we’re trying to level the playing field for everyone by making an objective standard way of programming,” explains Heldman. “We’re taking the guesswork out of it.”
 
While phase I will just collect preliminary data, deep brain stimulation could be another application for GLNT’s Kinesia. “It’s great for us,” Heldman says. “We have this sensor technology now, it’s released and it’s FDA cleared. This is just another application. Assuming we get good results, we'll apply for a much larger study.”
 
GLNT grew from 15 to 23 employees last year, and is hiring three additional people now.

 
Source: Dustin Heldman
Writer: Karin Connelly

In 2012, Northeast Ohio was a popular place for venture capitalists and angel investors to back startup companies. Investments nationally decreased by 10 percent last year, and decreased in the rest of Ohio by 33 percent, according to a study in The MoneyTree Report by PricewaterhouseCoopers and the National Venture Capital Association.
 
But in Northeast Ohio, according to the Northeast Ohio Venture Capital Advisory Task Force, 105 tech-based companies in Greater Cleveland raised $201 million from venture capitalists and angel investors -- a 34-percent increase over the amount raised by companies in 2011.
 
“We’ve been on an upward trajectory of the number of companies that have been able to raise money,” says Samantha Fryberger, vice president of marketing for JumpStart. “There’s a strong angel community here and our angels are well organized and well educated.”
 
In fact, Northeast Ohio has the first and fifth largest angel funds in the country. Fryberger says the diversity of businesses and the number of support organizations attract investors to Northeast Ohio. 
 
“We have a very robust early-stage investment ecosystem right here in Northeast Ohio,” says Clay Rankin, managing member of the North Coast Angel Fund, which invests in life sciences companies and is the country’s fifth largest angel group. “We’ve been building a lot of momentum in the last six to eight years. We’ve been very fortunate in supporting early stage ventures.”
 
Citing successful companies like Juventas Therapeutics, Cleveland HeartLab and Neuros Medical, Rankin says it’s no wonder Cleveland is growing in investments. “There really are world class companies being developed right here in our backyard,” he says. “When you have world class companies, you attract support from angel groups.”

 
Source: Samantha Fryberger and Clay Rankin
Writer: Karin Connelly

SafeCare, which provides continuous monitoring and background checks of employees in the healthcare industry, received a $25,000 grant in November from the Innovation Fund. The money will help SafeCare expand and refocus the company, which was formed out of Bizdom Cleveland’s inaugural class in April 2012.

The grant will allow SafeCare to concentrate more on the B2B market, rather than the consumer market. The company monitors employees on a monthly basis against nationwide healthcare and criminal public data sources.

“We will be using that money to really concentrate on flushing out our B2B offerings,” explains SafeCare founder and CEO Lissette Rivera. “We’re moving away from consumer products because of the sticky situations you can have when you share people’s information.”
 
SafeCare is in the process of re-designing their website to create a more personal feel. “We’re focused on providers rather than families, and our website will have a more warm and fuzzy feel,” Rivera says. The new website should launch by the end of this month.
 
SafeCare has three clients spanning nine healthcare facilities. Rivera has grown the company to four employees -- a CTO, two contract employees and a paid intern -- and is hoping to hire a salesperson in the next six months. “We’re fast moving in the direction of creating more and more jobs,” boasts Rivera.

 
Source: Lissette Rivera
Writer: Karin Connelly

What started as a design project in CWRU mechanical and aerospace engineering student Kristen Brouwer’s senior design class has evolved into a full-blown business. Brouwer and three of her classmates took an existing patent for a regenerative braking flywheel and created FlyDrive, which makes a flywheel that replaces the battery in electric and hybrid cars. They are bringing their flywheel to market.

“In a Prius, for instance, when you brake, the electric motors are charged, which then charge the battery,” says Brouwer. “With our flywheel, it’s just as efficient in returning energy and doesn’t have to be replaced. And it’s environmentally better than batteries because it doesn’t use chemicals.”
 
Brouwer and teammates Jordan Lajoie, Luke Voigt, Kris Bosma and Cleveland Institute of Art industrial design student Adam Lauser have been developing the flywheel for market since September. “Most of our developments have stemmed from market identification and development as well as creating a preliminary concept for implementing the flywheel in a transportation system,” says Brouwer.

FlyDrive will be competing in the Ohio Clean Energy Challenge semi-finals next week, where they will compete for $10,000 and the chance to move on the Midwest regional competition in Chicago. The company has been assessing licensing options in the meantime.

“We’re waiting to see if we make it to the next level of competition,” says Brouwer. “It’s been a great learning experience.”


Source: Kristen Brouwer
Writer: Karin Connelly

This story was originally published in Fresh Water Cleveland, hiVelocity's sister publication in Northeast Ohio.

JumpStart recently invested $250,000 in Guided Interventions, a startup company that has developed technology to assess coronary artery blockages. The company was formed two years ago and has been mainly focused on developing its intellectual property and proof of concepts, says Guided Interventions CEO Matthew Pollman.

“The concept is revolutionary,” Pollman says. “It uses a pressurized guideline to measure fractional flow reserve (FFR). It facilitates assessing blockages in the coronary artery and determines whether to perform an intervention.”
 
Pollman cites a clinical study, published in the New England Journal of Medicine, that showed using technologies like Guided Interventions’ FFR product instead of traditional angiogram indicate that 37 percent of the time the blockage should be left alone. “Sometimes leaving it alone is actually the best thing for patients,” he says.
 
Pollman plans to use the JumpStart investment to build out operations at GLIDE and the SMART Commercialization Center for Microsystems at Lorain County Community College.
 
The money will also allow the company to hire as many as six employees in the next two years, in particular engineers, and then triple or even quadruple the number of employees in the next three to five years. Currently, Pollman and his partner, Reinhard Warnking, are the only two employees.
 
Pollman, who is in the process of moving to Northeast Ohio from California, says he is looking forward to moving to a region that is so supportive of startup biotechnology companies and research.

 
Source: Matthew Pollman
Writer: Karin Connelly

Phil Alexander and Mohit Ahluwalia realized something when they were earning their MBAs at CWRU: that people in all segments of businesses are charged with creating presentations at some point in their careers. However, not everyone has the talent -- or budget to hire an agency -- to create an eye-catching presentation.

“Thirty million PowerPoint presentations are made every day across America,” says Alexander.
 
So Alexander and Ahluwalia thought about starting a business that would help customers create their presentations.

“We wanted to do something with digital media,” recalls Alexander. “We were looking to figure out if we could automate the process and avoid paying the high rates of agencies.”
 
The two applied to LaunchHouse Accelerator last summer and developed Quick2Launch, a company that creates great visuals for any presentation. The company officially launched last week with its ConceptDrop technology.
 
With the company’s ConceptDrop, users login, upload their content outlines and fill out a creative brief questionnaire describing their presentation. They are then presented with a selection of pre-approved templates and themes, and Quick2Launch takes it from there and creates the visuals to go along with the content. The end result is a complete, professional presentation.
 
“We’re just trying to hold their hand throughout the creation of the presentation,” says Alexander. “We’ve tried to make it so it’s really simple.”
 
Quick2Launch partners with Reality Premedia Services, which provides access to 150 graphic designers. The company is about a month away from launching its business-to-business platform.
 
Alexander says they hope to hire a sales team and in-house designers soon. “The goal is to completely build our own entity,” he says. “We really want to be the all-in-one stop for presentations.”

 
Source: Phil Alexander
Writer: Karin Connelly

This story was originally published in Fresh Water Cleveland, hiVelocity's sister publication in Northeast Ohio.

What began as a game and website development company in 1996 has blossomed into a thriving developer of software products.

After creating internal software that allowed UrbanCode to track the progress of its own software development projects, the company began developing similar products for its customers. UrbanCode products help their customers get their software to production faster -- decreasing time to market and ultimately getting their technology to the end users quickly and easily.
 
“One trait that unites all our customers is that they realize the strategic importance of their technology,” says Maciej Zawadzki, UrbanCode cofounder and CEO. “They need to get their technology into the hands of end users as quickly as possible. Our products facilitate the adoption of Agile methodologies in development and DevOps practices in operations."
 
Last year, UrbanCode was a finalist for Tech Company of the Year in NEOSA’s Best of Tech Awards, and its AnthillPro product won Best Software Product, Impact in 2008.
 
By recognizing their clients’ needs, UrbanCode has been growing by leaps and bounds. “Recently, we have been focused on DevOps releasing three new products: uDeploy, uBuild and uRelease,” says Tracy Gavlak, UrbanCode’s office manager. “We have been able to increase our growth rate to 70 percent over the last two years, with no signs of slowing down.”
 
UrbanCode has grown from 25 employees to 55 in the past year. Gavlak cites finding the right talent as one of the company’s biggest challenges. The company is currently recruiting sales engineers, field sales executives and software developers.

“We have the energy and informal atmosphere of a start-up, with the customers and financial security of a much larger firm” says Gavlak.
 
Company officials expect to double in size again this year. Plans are underway to move to a larger space in the Halle Building later this year.

 
Source: Maciej Zawadzki and Tracy Gavlak
Writer: Karin Connelly

This story was originally published in Fresh Water Cleveland, hiVelocity's sister publication in Northeast Ohio.

Nonprofit venture development organization JumpStart has awarded $250,000 to Guided Interventions, a medical startup that will call the Great Lakes Innovation and Development Enterprise (GLIDE) in Elyria home.
 
The grant will go toward Guided Interventions’ project to commercialize a new product that uses pressure sensors to better assess the physiological impact of coronary artery blockages at a more affordable cost. Cardiologist and CEO, Dr. Matthew Pollman, says the funding was the “tipping point” for their decision to locate in Northeast Ohio.
 
“The support from JumpStart was absolutely critical,” says Pollman. “The reward provides us with the opportunity to quickly take our company to the next level of growth.”
 
Pollman now turns to Ohio after co-founding a medical device company in the San Francisco Bay area in 2008, CV Ingenuity. During a period of economic duress across the country, Pollman found a more supportive environment for entrepreneurs in Northeast Ohio. He notes, “The contrasts with Northeast Ohio couldn’t be more stark.”
 
Once CV Ingenuity was acquired by Covidien earlier this month, Pollman took the opportunity to return to his childhood state where he has served as a member of the Global Cardiovascular Innovation Center’s advisory board in Cleveland since 2007. He sees tremendous promise in the state of Ohio’s entrepreneurial and innovation community.
 
“I have witnessed first hand how proactive the state of Ohio has been in promoting and supporting the build out of a critical mass of technical talent and infrastructure to foster and nurture technology development companies at all stages of their growth.”
 
 
Source: Dr. Matthew Pollman
Writer: Joe Baur

Jonathan Yale has always been socially conscious. As an athlete, he is also concerned about what foods he puts into his body. Those two principles came together when Yale and Phillip Williams founded HooftyMatch last August, an online marketplace for buying and selling locally produced meats.

“It started from a nutritional aspect,” says Yale. “I actually went to farms and bought some whole animals. I started educating myself on all the different factors of why it’s better meat.”

Yale and Williams came up with the idea for HooftyMatch after seeing a booming trend in farm-to-table eating and a strong desire to consume meat from humanely treated animals.
 
“We focus on farmers and the trend of beef without hormones or antibiotics,” says Yale. “We want to make that higher-quality product easier to get into the market. We want to have a consumer-friendly product where our customers can buy directly from our site and have it shipped to them or they can pick it up from a set location.”
 
A portfolio company in LaunchHouse Accelerator, HooftyMatch received a $25,000 investment. The company also won Startup Lakewood’s Ideation Challenge last summer.
 
Yale plans on starting a monthly Cleveland Meat Series with "localvore" restaurants to market HooftyMatch and educate people. “There are definitely people who want this and we want to say it’s out there,” he says. “It's good for farmers, it’s good for the restaurant business, and it’s good for people. It’s kind of like a win-win-win.”
 
HooftyMatch plans to officially launch its site next month.

This story originally appeared in Fresh Water Cleveland, our sister publication in Northeast Ohio.
 
Source: Jonathan Yale
Writer: Karin Connelly

When Dave Lazor founded Lazorpoint nearly 16 years ago, he had a vision of building a full-service IT firm that would allow clients to focus on what they do best and not worry about whether their information services capabilities were the right match.

“We think, build and run informational systems that instill confidence,” explains Lazor. “Entrepreneurs or mid-market CEOs are focused on running their businesses and servicing their customers. They know they need information services, but they don’t know anything about it. They need a point man.”
 
And a point man is exactly what Lazorpoint provides. Each client is assigned a point man, who makes sure every need is met. “They have a vision: the point man can provide the leadership,” says Lazor. “When there are problems, or opportunities, we provide the leadership to make things happen.”
 
Lazor makes sure all of his 22 employees are dedicated to their clients’ needs. “The people we hire are very passionate about serving our clients,” he says. “We are relentless in whatever mission we’re on. We go beyond just the technology. We look at the people process.”
 
An example of the point man philosophy at work is demonstrated in an instance where a client had a warehouse fire.

“The client called his point man at 11 p.m. on a Saturday night and asked if we could help,” recalls Lazor. “At 8 a.m. Sunday we were on site. They were back in business Monday morning, with emails getting through. No one knew they had this problem.”
 
The point man approach has proved successful for Lazorpoint. The company has been named to the Weatherhead 100 as one of the fastest growing companies in Northeast Ohio eight times. Lazorpoint hired two additional people last year, and recently brought in a co-op student for a second year. The company currently has one open position, plans on hiring two interns this summer and creating another full-time position later this year.

Originally published in Fresh Water Cleveland, our sister publication in Northeast Ohio.
 
Source: Dave Lazor
Writer: Karin Connelly

Success didn’t come in a blinding “aha” moment, but Andy Zsinko ultimately met a challenge from a buddy to create a unique, long-lasting motorcycle paint job.
 
Zsinko, founder and chief executive officer of Darkside Scientific in Medina, initially created a sprayable photoluminescent coating that made the motorcycle dazzle. The problem was that it looked that way for only a short time.
 
After several months of tinkering, however, Zsinko created LumiLor Electroluminescent paint, which continues glowing when electrically energized. It’s the world’s first and only such specialty coating, and the company has several patents pending for it.
 
Electroluminescence is an optical and electrical condition created when a material emits light in response to an electric current, explains Scott Smith, Darkside Scientific’s vice president of sales and marketing.
 
“Our LumiLor Electroluminescent paint is activated by an electric current and lights up with simple driver electronics,” he says. “A basic electronics package retrofitted on a motorcycle or car is all that’s needed.”   
 
Smith notes that the new paint can be used to create different special visual effects. “You can paint multiple fields on your vehicle to animate your paint job, and strobing and sound activation are also among many possible electronic effects with LumiLor.”
 
The company is developing a network of auto and motorcycle shops to become licensed to apply LumiLor paint. “We’re choosing partners carefully, based on their experience, expertise and capabilities,” Smith explains. “They’ll go through special training and a rigorous certification process to ensure that the work they do represents the quality brand image we’re looking to portray.”
 
Darkside Scientific plans to make a big splash this March by debuting the world’s first fully electroluminescent-painted motorcycle at Daytona, Florida’s, special Bike Week.
 
The firm, which was established in 2011, has six employees and plans to expand as business grows.


Source: Scott Smith
Writer: Lynne Meyer

When Deej Lincoln bought Interior Products Company two years ago, he thought he would build upon the commercial millwork company’s reputation for creating beautiful libraries. While the company continues to do library work, a new business built on sustainability, recycling and a bit of nostalgia has evolved.

Reclaimed Cleveland harvests wood from Cleveland properties slated for demolition and turns what they find into functional works of art. “We wanted to build the business in a new direction, and we got into wood reclamation,” explains Lincoln. “The idea resonated with our Interior Products Company customers.”
 
From benches and console tables to bottle openers and iPhone skins, every Reclaimed Cleveland product is stamped with the address of the property from which it came. Much of the focus is on old homes, which have a lot of old-growth wood, and churches.
 
“Obviously, there’s a sustainability component to it,” says Lincoln. “But there’s an aesthetic component that comes from a talented designer.”
 
The inspiration to create products from reclaimed wood came almost out of necessity. “About a year ago, we were sitting on all this wood and we had no furniture designed or built,” says Lincoln. “I said we have to have some holiday gift items at a low price point.”
 
From there, Reclaimed Cleveland made a bottle opener and marketed it through flash sales. “We immediately sold out of them,” says Lincoln. “We were impressed and pleased with the fact it took off as well as it did. I regret as a company, we didn’t do it sooner.” The products have even found a following outside of Cleveland.
 
Aaron Gogolin, who co-founded A Piece of Cleveland (APOC), joined the company in 2011 He helped produce the original products for Reclaimed Cleveland and helps maintain assembly and design standards. David Meyers joined in 2011 and is key in new product designs and branding of Reclaimed Cleveland. The company employs a total of 12 people.

 
Source: Deej Lincoln
Writer: Karin Connelly

Milo Biotechnology, a BioEnterprise startup created to find therapies for neuromuscular diseases, received FDA orphan drug designation for its AAV1-FS344, a drug that increases muscle strength.
 
The drug is a myostatin inhibitor that produces the protein follistatin, which increases muscle strength. Milo is focused on using the drug for treatment of Becker and Duchenne muscular dystrophy. In both types of the disease, patients have progressive muscle weakness and cardiac and respiratory degeneration. The drug also has potential uses in muscle degeneration in AIDS and cancer patients, but Milo's initial focus is on muscular dystrophy.
 
Orphan drug classification is given to therapies that treat diseases that affect less than 200,000 people nationwide. “Orphan says two things: One, it says this compound looks like it’s effective in some model of whatever disease it’s treating,” explains Al Hawkins, Milo CEO. “Second,  it means that the  target population is under 200,000 patients." The designation gives expedited regulatory review, seven years of post-market exclusivity and it qualifies for an FDA grant program in clinical trials.
 
Milo was founded about a year ago, after receiving a $250,000 investment  from JumpStart. The company also received funding from the North Coast Opportunities Technology fund.
 
Milo's drug is being used in clinical trials at Nationwide Children’s Hospital in Columbus with patients who have Becker muscular dystrophy and inclusion body myositis. Hawkins says the designation will expedite development of the therapy.
 
“There are no approved  drugs for muscular dystrophy, but there are a lot of promising therapies in development,” says Hawkins. “The community has banded together in supporting this, but we are still years away from getting to market.”


Source: Al Hawkins
Writer: Karin Connelly

This week BioEnterprise and Global Cleveland are hosting their fourth online biomedical job fair, hoping to attract top talent to the industry. “This is really driven by the growth in the biomedical sector in Northeast Ohio,” explains Aram Nerpouni, BioEnterprise interim CEO. “We’ve gone from 300 to 700 biomedical companies in the area. Cleveland is becoming a national hotbed for biomedical.”

The job fairs are an effective resource for employers. It is free for employers to post their listings and reach a wide population of qualified candidates. Arteriocyte, which does stem cell research for regenerating bones, has participated in three of the four job fairs this year. In each job fair the company has hired an employee.
 
“For us it’s appealing because it’s pretty easy as an employer,” explains Kolby Day, Arteriocyte‘s vice president and general manager of research and development. “We’ve seen really high caliber talent applying to the postings." Day says they’ve seen applicants from local schools as well as residents who left Cleveland and wish to return.
 
“We’ve interviewed a lot of people and, interestingly enough, they all want to be in Cleveland,” says Day. “A big part of that is how quickly the biotech industry is growing in Cleveland.”
 
Nerpouni points out that the online job fairs especially help the smaller employers. “For smaller companies that are growing rapidly and don’t have an HR staff, it helps them keep up with the pace of growth,” he says. “It’s much easier to hunt as a pack, so potential candidates aren’t looking at just one position.”
 
Close to 50 employers are participating in the job fair this week, posting 200 open positions. BioEnterprise plans to continue the biomedical jobs fairs on a quarterly basis.

 
Sources: Aram Nerpouni and Kolby Day
Writer: Karin Connelly

Donna Lee, CEO of MascotSecret, has always eyed with envy the vacant good seats at sporting events. She thought there had to be some way to get those unused good seats into the hands of those sitting in the cheap seats. So Lee and co-founder Jennifer Jeng set out to find a way.

“This is the problem we had growing up -- we always wanted better seats,” says Lee. “You go to the game, you see all the empty seats, and we thought there has to be a better solution.”
 
This past summer, Lee and Jeng moved to Cleveland from San Francisco to develop MascotSecret through Bizdom, a non-profit startup accelerator founded by Dan Gilbert, founder and chairman of Quicken Loans and majority owner of the Cleveland Cavaliers. “It allows you to upgrade your seats during game time through your mobile phone,” explains Lee. “All you need to do is open the app, put in how many tickets you want to upgrade, and then move to your new seats.”
 
Lee says the price to upgrade might be cheaper or more expensiver than face value depending on availability, the game, and other factors.
 
So far, MascotSecret has been testing the app at Cavs games. As a Bizdom company, they have gotten the support from Gilbert and Veritix. “We’ve had a really great response so far," says Lee. "Customers who have heard about it want to try it.”
 
MascotSecret recently received a $25,000 grant from the Lorain County Community College Foundation Innovation Fund, which they will use to further develop the app. The company is beginning talks with the Indians to use the app. The goal is to sell the app to markets across the country.

“Of course we want to expand as quickly as possible,” says Lee. As they expand, the company will be looking for technical and marketing talent.

 
Source: Donna Lee
Writer: Karin Connelly