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Parched former football players launch OXYwater as sugar-free, no caffeine hydration drink

When Preston Harrison was playing football for the Ohio State Buckeyes in the mid-1990s, he wished that he had a sport drink that could hydrate and nourish him without sugar and caffeine.

Since he couldn't find such a drink,  he and his friend Tom Jackson decided to create one.  Last month, OXYwater, their brand of oxygen enhanced mineral water, began selling in select Columbus retailers.  The beverage will be available statewide in about three stores by the end of September, says Russell Pinto, marketing manager for OXYwater.

Pinto says Harrison and Jackson first came up with the idea for OXYwater back in their football playing days. 

"They felt there was nothing good out there for muscle cramping," he says.  "They also wanted a drink with no sugar."

While Pinto says that OXYwater doesn't proclaim any medical benefits, it does claim to offer the same antioxidant values of five servings of fruits and vegetables due to its heightened oxygen content.  The drink's website also claims that the increased oxygen can make the flavored water taste naturally sweeter.

With careers in the nutrition supplement business, Harrison and Jackson had some background in how to market a new nutritional sport beverage.

OXYwater has agreements with Whole Foods to carry the drink in its Ohio stores, as well as GNC retailers, Walgreens and some convenience markets.  By later this fall, Pinto says the product should also be available at retailers in neighboring states and throughout the country by the end of 2012.

The 20-ounce plastic bottle in three flavors sells for roughly $2.79.  First year sales are expected to reach up to $12 million, says Pinto.

The water is manufactured and bottled in Wisconsin, but all distribution is handled through the company's warehouse and headquarters in Westerville.  OXYwater has 20 employees now, and plans to hire at least 15 more by the end of its first year, says Pinto.

Source: Russell Pinto, OXYwater
Writer: Val Prevish

NoBull Innovations is catalyst for customers creating new products

New technologies are worthless if people and businesses can't easily use them. Sometimes it takes an outsider's view to take an innovation from a theory to its best practical use.

NoBull Innovation has been helping entrepreneurs and companies in Ohio and beyond develop new science and technology-based products, services and processes for more than three years. The owners have at times invested in some of these new technologies and helped launch startups in the process.

The Dayton firm works as an innovation catalyst creating new products through physical science, biology, electronics, and engineering. It works with clients who are early in the innovation process or who are trying to solve specific problems through technology.

NoBull was founded by former veteran Miami University chemistry professor Gilbert Pacey, former Procter & Gamble product developer and scientist Wolfgang Spendel and Todd Dockum, director of the Miami Heritage Technology Park. The company has two employees and is applying for federal grants that could allow them to hire two-to-three more in the next 12 months.

"People come to us who have a technology-based idea but need some help. We provide experience in developing technologies and help them get their idea to the next level. We also have people who have a good technology but are naive on the business end, and we can help them as well," Pacey says.

The company often helps clients discover multiple and new uses for their ideas beyond their preconceived notions.
"Sometimes people get tunnel vision and Wolf is really good at helping them see beyond that," Pacey adds.

Among the companies NoBull has worked with are Algaeventure Systems, Inc., a clean energy tech company in Marysville, and Applied Nanoinfusion and VCG Chromatography, both in Dayton. NoBull is partial owner of VCG.

NoBull is located in a facility of The Institute for Development and Commercialization of Advanced Sensor Technology, (or IDCAST).  IDCAST, is a research and development accelerator established through a $28 million Ohio Third Frontier grant.

Source: Gilbert Pacey, NoBull Innovation
Writer: Feoshia Henderson

Cincinnati Innovates highlights 12 southwest Ohio innovators

While chores may never make it to your child's bucket list, two Cincinnati entrepreneurs are developing a web-based and mobile application that can make them more enjoyable.

The idea was enough to garner Chris Bergman and Paul Armstrong's ChoreMonster a $25,000 CincyTech Commercialization award at this year's Cincinnati Innovates competition.

ChoreMonster, now under development, connects chores and rewards through a point system. The application, which can be accessed by parents and their children, awards kids points based on the type of chore they complete. The points can then be cashed in for real rewards like a gaming system or a night out at the movies.

ChoreMonster was among a dozen local entrepreneurs recently shared $115,000 in grants awarded by Cincinnati Innovates, a nonprofit in search of the "next big thing. Cincinnati startup Acceptd, which is developing web-based software designed to make it easier for university professionals to manage video applications for creative and sports programs, also won a $25,000 commercialization award.

"For the most part we're looking for entrepreneurs with a 'disruptive' innovation, with the potential to grow into great companies," says Elizabeth Edwards, founder of Metro Innovation and organizer of the competition. "These disruptive innovations have the potential to completely transform a marketplace."

In the past three years, more than 1,000 local entrepreneurs have participated in the annual competition, and winners have divvied up a total of $250,000 in grants provided by 23 sponsors. Past winners have raised over $3.5 million in follow-on capital, have been featured in national media, and are changing the world with their ideas.

This year's dozen innovators will save stroke victims, help travelers avoid missing flights, protect firefighters, stimulate kids to do their chores, and help to draft better fantasy sports teams.

"Cincinnati Innovates was a joint effort between CincyTech, the Taft law firm, Soapbox  and myself," says Edwards. "The awards are important in helping to identify aspiring entrepreneurs. Typically, aspiring entrepreneurs don't wear tee shirts that say, 'I'm thinking about starting a company.'"

She adds: "We are looking at things at the concept stage, before a business plan is even written . . . entrepreneurs must have a nearly transformational innovation and be serious about commercializing it. CincyTech, for example, has three awards . . . they're typically looking for healthcare and IT companies, something that offers a potential market exceeding 250 million dollars," says Edwards.

Other awards are outside the healthcare and IT markets.
 
Sources: Elizabeth A. Edwards, Metro Innovation; Soapbox
Writer: Patrick G. Mahoney

More than 300 expected at first Advanced Energy B2B Conference and Expo

Ohio may not have the sunshine or constant wind found elsewhere, but there's no doubt about it. Advanced and alternative energy is becoming a big deal in Ohio.

The growth of the industry is the catalyst for Nortech's first ever Advanced Energy B2B Conference and Expo Sept. 14 and 15 in downtown Akron, says Karen Allport, vice president of strategic outreach for the tech-based economic development organization serving northeast Ohio.

“Ohio has a very strong manufacturing base, innovative research facilities and a highly skilled workforce,” she explains. “In fact, we have more than 400 organizations, large and small, engaged in advanced energy research and manufacturing.”

Ohio leads the Great Lakes in offshore wind development, with wind farms throughout the state. Major studies are being conducted on fuel cells and photovoltaics, and Northeast Ohio is teeming with top-notch national and international manufacturers and research institutions.

Allport ticks off names of some Ohio companies involved in advanced energy.

“FirstEnergy is the nation’s fifth-largest investor owned electric utility,” Allport points out. Others include Eaton Corp., Lincoln Electric, Babcock & Wilcox, Cliffs Natural Resources, GE Lighting, Parker Hannifin, and the Timken Company, she notes. She also mentions ongoing energy research at Kent State University, the University of Akron, and Case Western Reserve University.

Consider this: Ohio is fourth in the country in the number of clean energy jobs, with 35,267 employees working in the state’s advanced energy industries. Ohio is sixth in the nation in number of clean technology businesses, for a total of 2,513 clean energy companies. We’re also seventh nationwide in the total number of clean energy patents filed -- 309 patents over the past decade.

There’s an international component to the Advanced Energy B2B Conference and Expo as well, according to Allport.

“We have a mayor’s association involved whose members want to showcase advanced energy activities in their communities, so they’re in touch with groups in India and Great Britain to generate interest in collaboration,” she explains. “Our overall goal with this energy conference and expo is to provide programs and exhibits that drive opportunities for commercial activities,” Allport notes.

With more than 300 people from all over Ohio and nationwide expected to attend and all 70 exhibit spaces already sold out for the upcoming conference, perhaps the combination of advanced energy + the state of Ohio will finally gets its due. 

Source:  Karen Allport, Nortech
Writer:  Lynne Meyer

UC's FETCH-LAB research helps pets, people

The idea of putting hearing aids on a dog may, to the uninitiated, seem like an extravagant splurge, the kind of move reserved for those with money to burn. But not to a team of researchers at the University of Cincinnati. It's one of several innovative projects designed to better understand how animals hear and communicate, with the hope of making the world more comfortable for both humans and our animal counterparts.

"This research has been going on for some time," says Pete Scheifele, PhD, head of UC's Facility for the Education and Testing of Canine Hearing and Lab Animal Bioacoustics (FETCH-LAB). "However, the noise impacts on animals have not been on the forefront, especially on animals that are domestic or captive."

Scheifele explains that, for years, vets and animal researchers paid little attention to hearing loss in animals such as domestic dogs. Owners who brought in their pets with concerns over hearing loss often saw vets use primitive tests, such as jingling keys or snapping and looking for reactions. When researchers started using pediatric hearing-test equipment to study dogs, however, an alarming trend surfaced: About 60 dog breeds showed a tendency toward congenital deafness, due in part to inbreeding.

"The awareness kind of shot up, because everyone's worried about having a deaf dog," he says. "It's had a domino effect."

Now, vets and researchers are working to identify causes of animal deafness, especially in service animals such as police and rescue dogs.

"Your job, perhaps your life, may depend on your working partner," Scheifele says.

FETCH-LAB scientists have also explored ways to combat excessive noise in places supposed to meet physical and mental needs. Kennels, for example, often have highly reflective walls and ceilings that bounce barks and yips into an annoying - and potentially harmful - cacophony.

"Kennels are made to be washed, not for hearing safety," he says.

The FETCH-LAB team recently installed sound-dampening panels at the League for Animal Welfare's kennel in Batavia, and is studying their effects on the sound levels and the health of both canine inhabitants and employees. And although Scheifele says testing is still underway, LFAW Director Mary Sue Bahr says that the panels are having a significant effect.

"Our goal for all of the dogs in our care is to provide a clean, healthy, friendly, stress-free environment for them,” says Bahr in a UC press release. "Having these sound panels helps us to fulfill that goal—and it’s also nice for our staff and volunteers. In reducing the sound levels, it helps them have a more enjoyable time here.”

Scieifele says FETCH-LAB also studies hearing and hearing loss in horses and marine animals, and is in the process of publishing a paper on optimizing aquarium design to provide stimulating - but not overwhelming - amounts of noise for captive inhabitants. The work, he explains, could both improve lives for animals, and could effect the way human hearing and noise control takes shape in the future.

"We often come back with information that's useful and say, 'we never thought about this in humans,'" he says. "We help the animals, and they help us."

Source: Pete Scheifele, University of Cincinnati
Writer: Matt Cunningham

This story originally appeared in sister publication Soapbox.

Heartlab's $18.4-million financing paves the way for faster growth

Cleveland HeartLab is moving quickly in the prevention and detection of cardiovascular disease. The company, spun off from the Cleveland Clinic in 2009, is a clinical laboratory and disease management startup that has developed a series of diagnostic tests for determining the risk of heart disease and stroke.
 
The company, which has grown from eight to 80 employees in two years, just completed an $18.4 million Series B financing round with Excel Venture Management and HealthCare Ventures, both out of Boston.
 
The investment will allow Cleveland HeartLab to expand -- both in employees and market acceptance. In addition to its current offerings, the company plans to introduce additional diagnostic tests in 2012. "The goal is to eliminate the threat of vascular inflammation," he says.
 
"The funding allows the company to double in size again," says Jake Orville, president and CEO. "And we've just committed to moving off [the Clinic's] campus to the Health Tech Corridor."
 
Orville predicts the company will double again in the next two years, adding positions in management, sales, marketing, and research and development. He attributes his company's growth to a talented, dedicated staff.

"We have the gift of really good novel technology," he says. "Combine that with really good people and a really good business plan."
 
Source: Jake Orville, HeartLab
Writer: Karin Connelly

This story originally appeared in sister publication Fresh Water Cleveland.

OSU College of Medicine lands $1.4-million grant to study brown algae's burn-healing power

In the world of medical research, the simplest answers can come from the strangest places. In the case of bacterial infections that take place after major burns, the answer may very well come from the sea.

Researchers at the Ohio State University College of Medicine, working with researchers in Norway, have landed a $1.4-million defense department grant to study the use of sea-produced brown algae and kelp to fight infections common to burns.

"The grant comes from the Department of Defense because of soldiers who suffer major burns in Afghanistan or Iraq," explains Dr. Chandan Sen, professor and vice chairman of research at OSUMC's Department of Surgery and one of the study's leaders. "Most of those burns get infected by bacteria like pseudomonas that thrive in desert areas. These bacteria form a biofilm, which defeats the kinds of antibiotics we typically use. They form a protective layer that antibiotics can't penetrate, and the infection gets worse. If you can't control the infection, ultimately it could lead to amputation or even death."

Though the genesis of the study was overseas casualties, the results of the study will have an impact worldwide. According to the Centers for Disease Control and Prevention, biofilms are linked to 60 percent of all chronic infections in the United States, even with its higher standard of health care. Pseudomonas itself was once responsible for more than half of all burn deaths in the U.S. Though that's no longer the case, the bacteria are living things, able to adapt. Over generations, they developed the ability to form the antibiotic-resistant biofilm.

The sea plants, Sen says, contain chemicals that have been shown to shut down the bacteria's ability to form that biofilm, once again making them vulnerable to common antibiotics.

"Once we can halt the production of the biofilm, we can kill the bacteria, and cure the infection," Sen points out. He doesn't find the answer to the biofilm problem odd, however.

"The fact of the matter is that bacteria are a part of nature and nature has its own way of controlling them," he says. Otherwise, bacteria would run rampant over the rest of the natural world.

"We humans can't produce the same chemicals, but nature has always had the answer," he says. "We're just looking to find a way to adapt nature's answer for use on humans."

The study, which has just begun and is expected to take a year to complete, includes researchers from OSU's Comprehensive Wound Care Center and the Dorothy M. Davis Heart and Lung Research Institute, along with their Norwegian colleagues.

Source: Dr. Chandan Sen, Ohio State University College of Medicine
Writer: Dave Malaska


iGuiders wants to give retailers 300-400 percent conversions to sales boost

If you were an online retail channel and could increase your conversions to sales by 350 to 400-percent, with a minimum investment in time and cost would you do it? 

iGuiders, a Cleveland startup company with an interactive online shopping and search application, is betting you would.  And, so far, iGuiders Founder & CEO, Jodi Marchewitz, has reason to believe.

iGuiders are interactive, decision-making applications that launch a Guided Shopping Experience ™ (GSE) directly from a link embedded into any digital marketing initiative, including social media, ads, websites and e-mails.  Given the customer's responses to a series of questions, the application guides the customer to the product or service that best fits their needs -- providing a virtual personal shopper.

Marchewitz says billions are lost in online sales each year simply because people cannot easily find what they're looking for. iGuiders are built specifically for each company, according to a set of questions and answers provided by the client, and are designed to lead the customer directly to purchase.

The company was founded by Marchewitz in 2008, with a grant from Cleveland's Civic Innovation Lab. iGuiders subsequently received two rounds of angel funding from JumpStart Ventures and has already served heavyweight clients such as Mattel, Kodak, Sports Authority, NFL, NHL, NBA, NASCAR and Skull Candy.

Now, iGuiders has signed with Value Click, as its exclusive ad network partner and has presented iGuiders demos to 70 of Value Clicks top clients. "We've given them the runway," Marchewitz says, "and we're excited about the potential Value Clicks brings to our exposure to the market."

The company has also grown from 4 to 6 employees.  "Because we created the app so that no coding is required, we are able to hire entry-level staff and bring them up to speed quickly," Marchewitz says. "Our most recent intern was writing iGuiders after one day."

And the growth potential for iGuiders?  Let's just say that Marchewitz is optimistic: 
"It's really a no-brainer for marketers when we can build the iGuiders in less than a day and increase their conversions immediately."

Source: Jodi Marchewitz, iGuiders
Writer: Dana Griffith


Ohio TechAngels grows to largest angel group in U.S.

Ohio TechAngels may not have been Ohio's first angel fund, but since its founding in 2004 it has grown to become the largest --  not just in Ohio, but in the entire United States.

Earlier this month, Entrepreneur pegged the Columbus-based investment group as the largest in the country with 282 members, ahead of Los Angeles's Tech Coast Angels, with 263 members.

Cleveland-based North Coast Angel Fund also made the top 10 list, coming in fifth with 180 members. Ohio was the only state with two angel groups in Entrepreneur's top 10.

John Huston, who formed Ohio TechAngels in 2004, says there never was a plan to grow the group to any particular size.

"I moved back to Ohio from Boston, where I was a banker, and after a year I was bored," he remembers. "What I missed was working with CEOs."

But when he looked for an angel fund in which to become involved, he could find none in central Ohio, he says. So, to learn how to start his own, he enrolled in a boot camp run by Ohio's first angel fund -- Cincinnati-based Queen City Angels.

Since then, Ohio TechAngels has offered three funds and made 53 investments in 33 Ohio-based, tech-related companies, Huston says.

He says Ohio's angel environment has four things going for it. First is the Ohio Technology Investment Tax Credit, which gives angel investors a 25 percent tax credit for investing in Ohio-based tech startups. Second is the Ohio Third Frontier's Innovation Ohio Loan Fund, which lends money to early stage companies.

"If you're an investor, that's non-dilutive capital, which increases return for shareholders," Huston says. "It provides access to debt before any commercial bank will lend to them. Half of the companies we've invested in have been able to borrow under that program."

A third strength of Ohio's angel environment is what Huston calls "a great infrastructure of incubators" that are equipped to assist early stage companies in ways that help them succeed. And fourth are the pre-seed grants provided by the Third Frontier, he says, noting that a substantial part of Ohio TechAngel's three funds -- some $6 million -- has consisted of state grants that include money from the Third Frontier. 

In the end, Huston says, it's not about how many members Ohio TechAngels has, but how many companies they help.

"The myth is that angels are a bunch of geezers with a lot of money who are trying to make a lot more money," he says. "What we're really trying to do is make meaning -- by building entrepreneurial wealth."

Source: John Huston, Ohio TechAngels
Writer: Gene Monteith


Cincinnati�s Innovative Card Solutions integrates prepaid cards with financial literacy

A Cincinnati-based financial-services company plans to issue prepaid MasterCards to 10,000 college students, thanks largely to an angel investment from William G. Mays (Mays Chemical in Indianapolis) and $250,000 from CincyTech.

Brothers Wyatt and Wade Goins formed Innovative Card Solutions 2008. They now have seven full-time employees. The business offers reloadable debit cards, online financial-literacy courses and money-management tools for businesses and college students.

"Other companies provide prepaid solutions but we integrate financial literacy with our program . . . everything from online money-management tools to financial literacy modules," explains Wade Goins, the company's chief marketing officer.
 
Twenty-three online training modules cover monthly budgeting, credit scores, identity theft and managing college loans. Other money-management tools include mobile messaging alerts.

ICS also helps corporations with direct payroll deposit for employees who don't have bank accounts. For college students, it's a convenient way to manage their money and access tuition refunds.

The company was founded "to teach financial literacy and provide under-served consumers a safe, convenient way of making purchases, paying bills and getting cash," says Goins.

"We use the prepaid card as a tool for behavior modification. We give them the tools they need to manage their money better," he says. "For the last two years we've been developing our technology platform. Now, we're in the launch phase, starting with five universities this fall."
 
The five universities are Urbana University, University of Evansville, Florida Memorial University, Trine University and Wilmington College.

Source: Wade Goins; Chief Marketing Officer, Innovative Card Solutions
Writer: Patrick G. Mahoney


Volunteer effort to thwart child abuse leads to possible multimillion dollar business

A volunteer effort to help prevent child abuse was the starting point for a what could become a multi-million dollar business for David Allburn.

A retired Air Force engineer, Allburn, 70, worked in counter intelligence during the Vietnam War era, and founded the Safe Harbor Foundation to Prevent Child Sexual Abuse about 10 years ago in Glouster.  The organization required its volunteers to be fingerprinted, but reliable, affordable, convenient methods of fingerprinting were not readily available.

That led Allburn to invent one.  Originally set up as part of his non-profit group, the fingerprinting was identified as a commercially viable idea, and he received $10,000 in grant money from the state of Ohio Third Frontier and help from Ohio University’s business school to get the venture rolling in 2009.

Today, National Fingerprint, uses “self capture packs” that are administered in the field by a network of contracted civilians, often notaries, who collect dozens of fingerprints that are mailed overnight to National Fingerprint’s lab in Glouster, which then selects the highest quality prints to forward to the Federal Bureau of Investigation’s lab for cross checking. 

The whole process takes just a couple of days, and costs an organization less than $300 per individual.  Previously, fingerprinting meant trips to a police station or similar official office.  It could then take weeks to get results.

“Our niche market is really VIPs who need quick, accurate fingerprinting,” says Allburn.  “We offer concierge service, so these executives don’t ever have to leave their office.  They can have results in just a couple of days.”

Many types of businesses that work with financial or government transactions require fingerprinting of each executive in the chain of command, says Allburn.  His fingerprint product is one of the only easy-to-use options for these applications.

Background check companies also distribute the packs so businesses can use them to help screen new hires or other workers.

Allburn says he expects $1 million in revenue in the next year, and foresees it as a $10 million business in the next five years in the fast growing security sector.  He has four employees now, but anticipates hiring a dozen more by the end of 2012.  These will be primarily lab technicians and will all be disabled veterans, he says.

Source: David Allburn, National Fingerprint
Writer: Val Prevish


SearchTeam allows groups to collaborate, work together online

A Cincinnati web entrepreneur has developed a new social search engine that allows groups to collaborate, organize and save topic searches with SearchTeam.com.

"Searching has been a lonely, solo activity to date.  But by delivering real-time as well as asynchronous collaborative searching, SearchTeam is bringing a fundamentally new way to search and research information in personal, education, business and other professional settings," says founder Sundar Kadayam.

The engine is an outgrowth of his Zakta.com search engine. Launched in 2009, Zakta was developed as personal engine that allows editing, saving and categorization of results.

It allows members to create profiles in a "SearchSpace," where they can invite others to search with them. Results can be saved into topic folders and others can "like" and comment on topic results. SearchTeam also has a chat feature that allows for coordination of searches.

Potential uses include vacation planning, genealogy research, R&D and patent research. The tool is especially useful in the educational realm, where students can use it for group research projects. Teachers, can use it in distance learning programs.

 "It really is imaginative and ingenious. The ability to work together as a group adds a whole new dimension to searching, especially for students who are used to working together in groups," Kadayam says.

Zakta is currently located in Blue Ash's Vora Innovation Center. The company has several interns and part-time employers, with plans to expand with some full-time employees later this year. The company has received investment from CincyTech, Vora Ventures and some private angel investors, Kadayam says.

Source: Sundar Kadayam, SearchTeam.com
Writer: Feoshia Henderson

You can follow Feoshia on Twitter @feoshiawrites

First Biotech�s gene-creation technology could benefit medicine, agriculture, research

Athens-based startup First Biotech Inc. (FBTI) believes it’s found a better way to create new genes that could lead to new applications in medicine and other fields.

First Biotech produces and markets research reagents for a new smart DNA technology referred to as Unrestricted Mutagenesis and Cloning (URMAC). The technology was developed by the company’s founder, Louay Hallak. 

The technology replaces conventional subcloning techniques -- techniques that transfer a cloned DNA fragment from one vector to another -- with fast biochemical reactions that allow direct manipulation of large DNA sequences in an efficient, reliable and cost-effective way. The company has plans to establish a manufacturing and service operation in Ohio University’s Innovation Center.

FBTI, which registered as a C-corporation last year, is in the process of forming a management team in preparation for launch later this year.

“The main product,” says Hallak, “is fully developed and ready to go to market. We are starting with a professional team of experts in management, marketing and biotechnology . . . we will add new jobs as needed . . . FBTI will manufacture biochemical reagents, mainly for DNA mutagenesis and cloning,” Hallak says.

Hallak says the company’s new technique “will enable users to create new genes in shorter time, with high accuracy and less overall cost than the competition.”

URMAC has wide application in many fields, such as medicine. It can be used to create protein therapeutics and viral vectors; in research, it can “knock out” or change genes to help understand their function; and it can be used in agriculture, for crop engineering. 
 
FBTI has received pre-seed funding approval from TechGrowth Ohio, in addition to an earlier grant from TechColumbus. Hallak expects the new venture will achieve profitability within 12 to 18 months of launching.

Source: Louay Hallak, Founder, First Biotech Inc.
Writer: Patrick G. Mahoney

AtriCure continues to grow, snags Third Frontier grant

A $1-million Ohio Third Frontier award will help West Chester-based AtriCure develop and bring to market a next-generation version of its successful AtriClip.

The left atrial appendage is a saclike part of the heart that has internal peaks and valleys. During atrial fibrillation -- an abnormal rhythm of the heart -- the appendage can pool with blood, causing clots that can migrate to the brain and cause strokes.

The Gillinov-Cosgrove Left Atrial Appendage Exclusion system, which the FDA approved  last year for use in open-heart procedures, is designed as a more effective way to close blood flow between the appendage and the atria, thus eliminating the possibility of clots forming there. 

“Today, the clip is approved to be used during the open heart procedure,” says Julie Piton, VP Finance and Chief Financial Officer. The Third Frontier award will help fund development of a minimally invasive version of the device.

AtriCure was formed in 2000 to commercialize and market products developed by Enable Medical Technologies. In August 2005, AtriCure went public and subsequently purchased Enable.

Since then, the company has become a leading medical device company in cardiac surgical ablation systems and systems for the exclusion of the left atrial appendage. Cardiac ablation procedures are used to destroy small areas of the heart that may be cause abnormal heart rhythms.

The company boasted record revenues of $16.8 for the second quarter, with strong growth in international markets. Piton says the company has about 235 employees and has added about 10 in the last year.

Looking ahead, she says the company is poised to become “the first surgical company to get an atrial fibrillation indication” from the FDA.

What that means is that, if approved by the FDA, the company will be able to market its ablation products as a treatment for atrial fibrillation. Currently, they can only be marketed for the ablation of cardiac tissue.

“The only reason you would ablate cardiac tissue is to treat atrial fibrillation,” she says. “But we can’t market our outcomes and we can’t talk to physicians about atrial fibrillation, we can only talk about the technical attributes of our products.”

Source: Julie Piton, AtriCure
Writer: Gene Monteith


Promising artificial lung development can mean long-term mobility for patients

A team of researchers has developed an artificial lung that uses regular air, not pure oxygen, and is portable, marking a huge step forward for people with acute and chronic lung disease. The research is a result of collaboration between Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center

"The most significant finding is that we have demonstrated a small scale, prototype artificial lung," says Joseph A. Potkay, research assistant professor in CWRU's department of electrical engineering and computer science. "It represents a major leap forward toward a self-contained, portable or implantable device that would use ambient air, rather than oxygen cylinders, and would thus give patients full mobility." 

Current artificial lung systems require heavy tanks of oxygen, limiting patients' portability -- and they can be used only on patients at rest. Also, the lifetime of the system is measured in days. This new prototype is much smaller in size -- equivalent to a natural lung. 

"These results prove that constructing a device with features similar in size to those found in the natural lung can result in large improvements in efficiency over current alternatives, thereby enabling portable devices," says Potkay. "This technology will be used in portable heart lung machines and portable systems for the treatment of acute and chronic lung disease or as a bridge to transplant." 

Potkay and his team began developing the lung in early 2008 and will begin animal testing in two years. Human trials should begin in 10 years. The research was funded by the U.S. Department of Veterans Affairs. Lung disease affects over 200 million people worldwide.

Source: Joseph A. Potkay
Writer: Karin Connelly

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