ACME Express wants to take $35 million a year out of Ohio healthcare costs. So far, it's received a lot of help to pave the way. This Cleveland-based software developer has caught the attention both of the federal government and the State of Ohio, which have helped fund research and development as well as commercialization of software that makes scheduling of medical personnel more efficient. Founded in 1980, the company since then has developed products and services aimed at everything from logistics, to education, to medicine. These days, however, ACME is focused on healthcare. Grants from the National Institutes of Health and the Ohio Third Frontier have made it possible. The company has been adding jobs in addition to attracting interns through the Third Frontier Internship Program.